Seth Glier was born in Shelburne Falls, MA.and subsequently studied at Pioneer Valley Performing Arts Charter School PVPA in South Hadley, Massachusetts. He attended Berklee College of Music for a year before dropping out to be able to tour full-time. Since then, he has averaged over 200 shows a year, and shared stages with artists such as James Taylor, Mark Knopfler, The Verve Pipe, Edwin McCain and Ani DiFranco. He has appeared as a mainstage artist at the Falcon Ridge Folk Festival (NY) and the Kerrville Folk Festival (TX). USA Today compared Seth to Bruce Springsteen and Billy Joel.
In 2015, he released If I Could Change One Thing, his fourth album on MPress Records. The album was considered a successful move into mainstream pop, a departure from his previous, more acoustic albums. A music video for the title track, a duet with American Idol alum Crystal Bowersox, premiered on Billboard.com.
In 2016, Glier gave a TEDx talk sharing his insight on the challenges and gifts of care giving for a family member, and how it influences his life, art and music.